Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques | Zendy

Xuan He | Zendy; Abishek Chandrashekar | Zendy; Roland Zahn | Zendy; Frank Wegmann | Zendy; Jingyou Yu | Zendy; Noe B. Mercado | Zendy; Katherine McMahan | Zendy; Amanda J. Martinot | Zendy; César Piedra-Mora | Zendy; Sidney Beecy | Zendy; Sarah Ducat | Zendy; Ronnie Chamanza | Zendy; Sietske K. Rosendahl Huber | Zendy; Marjolein van Heerden | Zendy; Leslie van der Fits | Zendy; Erica N. Borducchi | Zendy; Michelle A. Lifton | Zendy; Jinyan Liu | Zendy; Felix Nampanya | Zendy; Shivani Patel | Zendy; Lauren Peter | Zendy; Lisa H. Tostanoski | Zendy; Laurent Pessaint | Zendy; Alex Van Ry | Zendy; Brad Finneyfrock | Zendy; Jason Velasco | Zendy; Elyse Teow | Zendy; Renita Brown | Zendy; Anthony Cook | Zendy; Hanné Andersen | Zendy; Mark G. Lewis | Zendy; Hanneke Schuitemaker | Zendy; Dan H. Barouch | Zendy

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Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques

Author(s) -

Xuan He,

Abishek Chandrashekar,

Roland Zahn,

Frank Wegmann,

Jingyou Yu,

Noe B. Mercado,

Katherine McMahan,

Amanda J. Martinot,

César Piedra-Mora,

Sidney Beecy,

Sarah Ducat,

Ronnie Chamanza,

Sietske K. Rosendahl Huber,

Marjolein van Heerden,

Leslie van der Fits,

Erica N. Borducchi,

Michelle A. Lifton,

Jinyan Liu,

Felix Nampanya,

Shivani Patel,

Lauren Peter,

Lisa H. Tostanoski,

Laurent Pessaint,

Alex Van Ry,

Brad Finneyfrock,

Jason Velasco,

Elyse Teow,

Renita Brown,

Anthony Cook,

Hanné Andersen,

Mark G. Lewis,

Hanneke Schuitemaker,

Dan H. Barouch

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.05.040

Subject(s) - biology , covid-19 , betacoronavirus , virology , genetics , medicine , outbreak , infectious disease (medical specialty) , disease

We previously reported that a single immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing an optimized SARS-CoV-2 spike (Ad26.COV2.S) protected rhesus macaques against SARS-CoV-2 challenge. To evaluate reduced doses of Ad26.COV2.S, 30 rhesus macaques were immunized once with 1 × 10 11 , 5 × 10 10 , 1.125 × 10 10 , or 2 × 10 9 viral particles (vp) Ad26.COV2.S or sham and were challenged with SARS-CoV-2. Vaccine doses as low as 2 × 10 9 vp provided robust protection in bronchoalveolar lavage, whereas doses of 1.125 × 10 10 vp were required for protection in nasal swabs. Activated memory B cells and binding or neutralizing antibody titers following vaccination correlated with protective efficacy. At suboptimal vaccine doses, viral breakthrough was observed but did not show enhancement of disease. These data demonstrate that a single immunization with relatively low dose of Ad26.COV2.S effectively protected against SARS-CoV-2 challenge in rhesus macaques, although a higher vaccine dose may be required for protection in the upper respiratory tract.

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