Open AccessHow to make a better T cell: in vivo CRISPR screens have some answers
Author(s) -
Matteo Villa,
Michal A. Stanczak,
Erika L. Pearce
Publication year - 2021
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2021.02.003
Subject(s) - biology , crispr , in vivo , cell , cd8 , t cell , immunity , computational biology , genome editing , microbiology and biotechnology , genetics , immune system , gene
Understanding what regulates CD8 + T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8 + T cell immunity to engineer a more efficacious response against cancer and infections.
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