Multi-organ proteomic landscape of COVID-19 autopsies | Zendy

Xiu Nie | Zendy; Liujia Qian | Zendy; Rui Sun | Zendy; Bo Huang | Zendy; Xiaochuan Dong | Zendy; Qi Xiao | Zendy; Qiushi Zhang | Zendy; Tian Lu | Zendy; Liang Yue | Zendy; Shuo Chen | Zendy; Xiang Li | Zendy; Yaoting Sun | Zendy; Lu Li | Zendy; Luang Xu | Zendy; Yan Li | Zendy; Ming Yang | Zendy; Zhangzhi Xue | Zendy; Shuang Liang | Zendy; Xuan Ding | Zendy; Chunhui Yuan | Zendy; Li Peng | Zendy; Wei Liu | Zendy; Xiao Yi | Zendy; Mengge Lyu | Zendy; Guixiang Xiao | Zendy; Xia Xu | Zendy; Weigang Ge | Zendy; Jiale He | Zendy; Jun Fan | Zendy; Junhua Wu | Zendy; Meng Luo | Zendy; Xiaona Chang | Zendy; Huaxiong Pan | Zendy; Xue Cai | Zendy; Junjie Zhou | Zendy; Jing Yu | Zendy; Huanhuan Gao | Zendy; Mingxing Xie | Zendy; Sihua Wang | Zendy; Guan Ruan | Zendy; Hao Chen | Zendy; Hua Su | Zendy; Heng Mei | Zendy; Danju Luo | Zendy; Dashi Zhao | Zendy; Fei Xu | Zendy; Yi Zhu | Zendy; Jiahong Xia | Zendy; Yu Hu | Zendy; Tiannan Guo | Zendy

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Multi-organ proteomic landscape of COVID-19 autopsies

Author(s) -

Xiu Nie,

Liujia Qian,

Rui Sun,

Bo Huang,

Xiaochuan Dong,

Qi Xiao,

Qiushi Zhang,

Tian Lu,

Liang Yue,

Shuo Chen,

Xiang Li,

Yaoting Sun,

Lu Li,

Luang Xu,

Yan Li,

Ming Yang,

Zhangzhi Xue,

Shuang Liang,

Xuan Ding,

Chunhui Yuan,

Li Peng,

Wei Liu,

Xiao Yi,

Mengge Lyu,

Guixiang Xiao,

Xia Xu,

Weigang Ge,

Jiale He,

Jun Fan,

Junhua Wu,

Meng Luo,

Xiaona Chang,

Huaxiong Pan,

Xue Cai,

Junjie Zhou,

Jing Yu,

Huanhuan Gao,

Mingxing Xie,

Sihua Wang,

Guan Ruan,

Hao Chen,

Hua Su,

Heng Mei,

Danju Luo,

Dashi Zhao,

Fei Xu,

Yi Zhu,

Jiahong Xia,

Yu Hu,

Tiannan Guo

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.01.004

Subject(s) - biology , covid-19 , betacoronavirus , coronavirus infections , virology , computational biology , evolutionary biology , pathology , outbreak , disease , infectious disease (medical specialty) , medicine

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries include reduced Leydig cells, suppressed cholesterol biosynthesis and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology.

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