Open AccessMolecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise
Author(s) -
James Sanford,
Christopher D. Nogiec,
Maléne E. Lindholm,
Joshua Adkins,
David Amar,
Surendra Dasari,
Jonelle K. Drugan,
Facundo M. Fernández,
Shlomit RadomAizik,
Simon Schenk,
M Snyder,
Russell P. Tracy,
Patrick M. Vanderboom,
Scott Trappe,
Martin J. Walsh,
Charles R. Evans,
Yafeng Li,
Lyl Tomlinson,
D. Lee Alekel,
Iddil Bekirov,
Amanda Boyce,
Josephine Boyington,
Jerome L. Fleg,
Lyndon Joseph,
Maren R. Laughlin,
Padma Maruvada,
Stephanie A. Morris,
Joan McGowan,
Concepcion R. Nierras,
Vinay Pai,
Charlotte A. Peterson,
Ed Ramos,
Mary Roary,
John Williams,
Ashley Xia,
Elaine Cornell,
Jessica L. Rooney,
Michael E. Miller,
Walter T. Ambrosius,
Scott Rushing,
Cynthia L. Stowe,
W. Jack Rejeski,
Barbara J. Nicklas,
Marco Pahor,
Ching-ju Lu,
Todd A. Trappe,
Toby L. Chambers,
Ulrika Raue,
Bridget Lester,
Bryan C. Bergman,
David H. Bessesen,
Catherine M. Jankowski,
Wendy M. Kohrt,
Edward L. Melanson,
Kerrie L. Moreau,
Irene E. Schauer,
Robert S. Schwartz,
William E. Kraus,
Cris A. Slentz,
Kim M. Huffman,
Johanna L. Johnson,
Leslie H. Willis,
Leslie Kelly,
Joseph A. Houmard,
Gabriel S. Dubis,
Nicholas T. Broskey,
Bret H. Goodpaster,
Lauren M. Sparks,
Paul M. Coen,
Dan M. Cooper,
Fadia Haddad,
Tuomo Rankinen,
Éric Ravussin,
Neil M. Johannsen,
Melissa Harris,
John M. Jakicic,
Anne B. Newman,
Daniel D. Forman,
Erin E. Kershaw,
Renee J. Rogers,
Bradley C. Nindl,
Lindsay Page,
Maja Stefanović-Račić,
Susan L. Barr,
Blake B. Rasmussen,
Tatiana Moro,
Douglas PaddonJones,
Elena Volpi,
Heidi Spratt,
Nicolas Musi,
Sara Espinoza,
D.C. Patel,
Monica C. Serra,
Jonathan Gelfond,
Aisling Burns,
Marcas M. Bamman,
Thomas W. Buford,
Gary Cutter,
Sue C. Bodine,
Karyn A. Esser,
Rodger P. Farrar,
Laurie J. Goodyear,
Michael F. Hirshman,
Brent G. Albertson,
Weijun Qian,
Paul Piehowski,
Marina Gritsenko,
Matthew E. Monore,
Vladislav Petyuk,
Jason McDermott,
Joshua Hansen,
Chelsea Hutchison,
Samuel Moore,
David A. Gaul,
Clary B. Clish,
Julián Ávila-Pacheco,
Courtney Dennis,
Manolis Kellis,
Steve Carr,
Pierre M. Jean-Beltran,
Hasmik Keshishian,
DR Mani,
Karl R. Clauser,
Karsten Krug,
Charlie Mundorff,
Cadence Pearce,
Anna Ivanova,
Eric A. Ortlund,
Kristal Maner-Smith,
Karan Uppal,
Tiantian Zhang,
Stuart C. Sealfon,
Elena Zaslavsky,
Venugopalan D. Nair,
SiDe Li,
Nimisha Jain,
Yongchao Ge,
Yifei Sun,
German Nudelman,
Frederique Ruf-Zamojski,
Gregory R. Smith,
Nhanna Pincas,
Aliza B. Rubenstein,
Mary Anne S. Amper,
Nitish Seenarine,
Tuuli Lappalainen,
Ian R. Lanza,
K. Sreekumaran Nair,
Katherine A. Klaus,
Stephen B. Montgomery,
Kevin S. Smith,
Nicole R. Gay,
Bingqing Zhao,
Chia-Jiu Hung,
Navid Zebarjadi,
Brunilda Balliu,
Laure Frésard,
Charles Burant,
Jun Z. Li,
Maureen Kachman,
Tanu Soni,
Alexander Raskind,
Robert Gerszten,
Jeremy Robbins,
Olga Ilkayeva,
Michael J. Muehlbauer,
Christopher B. Newgard,
Euan A. Ashley,
Matthew T. Wheeler,
David JimenezMorales,
Archa. Raja,
Karen Dalton,
Jimmy Zhen,
Young Suk Kim,
Jeffrey W. Christle,
Shruti Marwaha,
Elizabeth T. Chin,
Steven G. Hershman,
Trevor Hastie,
Robert Tibshirani,
Manuel A. Rivas
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.06.004
Subject(s) - stimulus (psychology) , physical exercise , disease , endurance training , health benefits , physical fitness , exercise physiology , physical activity , biology , bioinformatics , medicine , physical medicine and rehabilitation , physical therapy , psychology , psychotherapist , traditional medicine
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
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