The Secret Life of lncRNAs: Conserved, yet Not Conserved | Zendy

Harshita Sharma | Zendy; Piero Carninci | Zendy

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The Secret Life of lncRNAs: Conserved, yet Not Conserved

Author(s) -

Harshita Sharma,

Piero Carninci

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.04.012

Subject(s) - biology , conserved sequence , function (biology) , rna splicing , cytoplasm , computational biology , genetics , alternative splicing , microbiology and biotechnology , evolutionary biology , rna , gene , messenger rna , base sequence

Guo and colleagues discover a new layer of complexity to the lncRNA evolution where positionally conserved lncRNAs in human ESCs are broadly spliced and exported to the cytoplasm contrary to their mouse counterpart that are predominantly unspliced and nuclear retained. Distinct processing leads to species-specific lncRNA function in pluripotency maintenance.

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