Open AccessTerminating G-Protein Coupling: Structural Snapshots of GPCR-β-Arrestin Complexes
Author(s) -
Madhu Chaturvedi,
Jagannath Maharana,
Arun K. Shukla
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.02.047
Subject(s) - biology , g protein coupled receptor , arrestin , computational biology , microbiology and biotechnology , evolutionary biology , signal transduction
β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction.
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