Open AccessChemotherapy Induces Cancer-Fighting B Cells
Author(s) -
Zhida Liu,
YangXin Fu
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2020.02.046
Subject(s) - biology , cancer research , immunity , chemotherapy , tumor cells , cancer cell , b cell , cancer , cell , complement (music) , immunology , microbiology and biotechnology , immune system , antibody , gene , genetics , phenotype , complementation
Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL + B cells, which enhance tumor-specific T cell responses.
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