Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging | Zendy

Shuai Ma | Zendy; Shuhui Sun | Zendy; Lingling Geng | Zendy; Moshi Song | Zendy; Wei Wang | Zendy; Yanxia Ye | Zendy; Qianzhao Ji | Zendy; Zhiran Zou | Zendy; Si Wang | Zendy; Xiaojuan He | Zendy; Wei Li | Zendy; Concepción Rodrı́guez Esteban | Zendy; Xiao Long | Zendy; Guoji Guo | Zendy; Piu Chan | Zendy; Qi Zhou | Zendy; Juan Carlos Izpisúa Belmonte | Zendy; Weiqi Zhang | Zendy; Jing Qu | Zendy; GuangHui Liu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

Author(s) -

Shuai Ma,

Shuhui Sun,

Lingling Geng,

Moshi Song,

Wei Wang,

Yanxia Ye,

Qianzhao Ji,

Zhiran Zou,

Si Wang,

Xiaojuan He,

Wei Li,

Concepción Rodrı́guez Esteban,

Xiao Long,

Guoji Guo,

Piu Chan,

Qi Zhou,

Juan Carlos Izpisúa Belmonte,

Weiqi Zhang,

Jing Qu,

GuangHui Liu

Publication year - 2020

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2020.02.008

Subject(s) - biology , transcriptome , immune system , senescence , cell , caloric theory , microbiology and biotechnology , proinflammatory cytokine , neuroscience , gene expression , gene , immunology , inflammation , genetics , endocrinology

Aging causes a functional decline in tissues throughout the body that may be delayed by caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as those ameliorated by CR, remain unclear. Here, we built comprehensive single-cell and single-nucleus transcriptomic atlases across various rat tissues undergoing aging and CR. CR attenuated aging-related changes in cell type composition, gene expression, and core transcriptional regulatory networks. Immune cells were increased during aging, and CR favorably reversed the aging-disturbed immune ecosystem. Computational prediction revealed that the abnormal cell-cell communication patterns observed during aging, including the excessive proinflammatory ligand-receptor interplay, were reversed by CR. Our work provides multi-tissue single-cell transcriptional landscapes associated with aging and CR in a mammal, enhances our understanding of the robustness of CR as a geroprotective intervention, and uncovers how metabolic intervention can act upon the immune system to modify the process of aging.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research