Open AccessA Single Transcription Factor Drives Toxoplasma gondii Differentiation
Author(s) -
Joshua A. Kochanowsky,
Anita A. Koshy
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.12.038
Subject(s) - lytic cycle , biology , toxoplasma gondii , transcription factor , virology , genetics , transcription (linguistics) , virus , gene , antibody , linguistics , philosophy
Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persistent brain infection.
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