Open AccessMay the (Mechanical) Force Be with AT2
Author(s) -
Julio Sainz de Aja,
Carla F. Kim
Publication year - 2020
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.12.020
Subject(s) - biology , pulmonary fibrosis , fibrosis , lung , lung disease , idiopathic pulmonary fibrosis , disease , immunology , stem cell , microbiology and biotechnology , pathology , medicine
Idiopathic pulmonary fibrosis is a fatal disease involving destruction of the lung alveolar structure. In this issue of Cell, Wu et al. (2020) show that impaired alveolar (AT2) stem cells produce mechanical tension that leads to spatially regulated fibrosis, initiating a new chapter in understanding what underlies the periphery to center progression of this lung disease.
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