Open AccessSplicing Calls Back
Author(s) -
Tobias Hoffmann,
Juan Valcárcel
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.11.028
Subject(s) - biology , intron , rna splicing , exon , mature messenger rna , transcription (linguistics) , gene , post transcriptional modification , genetics , messenger rna , alternative splicing , rna , gene expression , computational biology , microbiology and biotechnology , linguistics , philosophy
Removal of introns from eukaryotic messenger RNA precursors often occurs co-transcriptionally. In this issue of Cell, Fiszbein et al. report that evolutionary or tissue-specific activation of an internal exon can enhance gene expression by promoting the use of alternative transcription initiation sites.
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