Open AccessMammalian Mediator as a Functional Link between Enhancers and Promoters
Author(s) -
Julie Soutourina
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.07.040
Subject(s) - biology , mediator , promoter , enhancer , link (geometry) , genetics , computational biology , microbiology and biotechnology , transcription factor , gene , gene expression , computer network , computer science
In this issue of Cell, Casellas and colleagues provide insights into the structural and functional aspects of the mammalian multi-subunit Mediator complex, a conserved and essential transcriptional coregulator. Combining cryo-EM, genetic, and genomic analyses, the work sheds light on Mediator's mode of action as a functional bridge between enhancers and promoters.
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