Open AccessDissecting Cell Lineages: From Microscope to Kaleidoscope
Author(s) -
Unmesh Jadhav,
Ramesh A. Shivdasani
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2019.01.054
Subject(s) - biology , kaleidoscope , microscope , evolutionary biology , microbiology and biotechnology , optics , visual arts , physics , art
Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real time. The authors' close examination of intestinal enteroendocrine differentiation reveals new lineage features and shifting cell identities, and experiments in organoids uncover specific roles for transcriptional regulators identified by this approach.
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