Open AccessStars Are Not in Outer Space: Astrocytes Respond to Environmental Cues
Author(s) -
Thomas Korn
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.12.025
Subject(s) - biology , zebrafish , microbiology and biotechnology , in vivo , astrocyte , inflammatory response , inflammation , neuroscience , immunology , genetics , gene , central nervous system
By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.
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