Open AccessAn Allosteric Switch Primes Sequence-Specific DNA Recognition
Author(s) -
Matthew Walker,
Gabriele Varani
Publication year - 2019
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.12.020
Subject(s) - biology , allosteric regulation , sequence (biology) , dna , genetics , dna sequencing , computational biology , recognition sequence , receptor , restriction enzyme
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
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