Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10 | Zendy

Olga L. Rojas | Zendy; AnneKatrin Pröbstel | Zendy; Elisa A. Porfilio | Zendy; A. Wang | Zendy; Marc Charabati | Zendy; Tian Sun | Zendy; Dennis S. W. Lee | Zendy; Georgina Galicia | Zendy; Valeria Ramaglia | Zendy; Lesley A. Ward | Zendy; Leslie Y. T. Leung | Zendy; Ghazal Najafi | Zendy; Khashayar Khaleghi | Zendy; Beatriz Garcillán | Zendy; Angela Li | Zendy; Rickvinder Besla | Zendy; Ikbel Naouar | Zendy; Eric Cao | Zendy; Pailin Chiaranunt | Zendy; Kyle Burrows | Zendy; Hannah G Robinson | Zendy; Jessica R. Allanach | Zendy; Jennifer Yam | Zendy; Helen Luck | Zendy; Daniel Campbell | Zendy; David Allman | Zendy; David G. Brooks | Zendy; Michio Tomura | Zendy; Ryan Baumann | Zendy; Scott S. Zamvil | Zendy; Amit BarOr | Zendy; Marc S. Horwitz | Zendy; Daniel A. Winer | Zendy; Arthur Mortha | Zendy; Fabienne Mackay | Zendy; Alexandre Prat | Zendy; Lisa C. Osborne | Zendy; Clinton S. Robbins | Zendy; Sergio E. Baranzini | Zendy; Jennifer L. Gommerman | Zendy

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Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

Author(s) -

Olga L. Rojas,

AnneKatrin Pröbstel,

Elisa A. Porfilio,

A. Wang,

Marc Charabati,

Tian Sun,

Dennis S. W. Lee,

Georgina Galicia,

Valeria Ramaglia,

Lesley A. Ward,

Leslie Y. T. Leung,

Ghazal Najafi,

Khashayar Khaleghi,

Beatriz Garcillán,

Angela Li,

Rickvinder Besla,

Ikbel Naouar,

Eric Cao,

Pailin Chiaranunt,

Kyle Burrows,

Hannah G Robinson,

Jessica R. Allanach,

Jennifer Yam,

Helen Luck,

Daniel Campbell,

David Allman,

David G. Brooks,

Michio Tomura,

Ryan Baumann,

Scott S. Zamvil,

Amit BarOr,

Marc S. Horwitz,

Daniel A. Winer,

Arthur Mortha,

Fabienne Mackay,

Alexandre Prat,

Lisa C. Osborne,

Clinton S. Robbins,

Sergio E. Baranzini,

Jennifer L. Gommerman

Publication year - 2019

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.11.035

Subject(s) - biology , neuroinflammation , microbiology and biotechnology , immunology , inflammation

Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source and role in MS remains unclear. We find that some PC in the CNS of mice with experimental autoimmune encephalomyelitis (EAE) originate in the gut and produce immunoglobulin A (IgA). Moreover, we show that IgA + PC are dramatically reduced in the gut during EAE, and likewise, a reduction in IgA-bound fecal bacteria is seen in MS patients during disease relapse. Removal of plasmablast (PB) plus PC resulted in exacerbated EAE that was normalized by the introduction of gut-derived IgA + PC. Furthermore, mice with an over-abundance of IgA + PB and/or PC were specifically resistant to the effector stage of EAE, and expression of interleukin (IL)-10 by PB plus PC was necessary and sufficient to confer resistance. Our data show that IgA + PB and/or PC mobilized from the gut play an unexpected role in suppressing neuroinflammation.

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