Open AccessPhase Separation, Protein Disorder, and Enhancer Function
Author(s) -
Steven Hahn
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.11.034
Subject(s) - biology , separation (statistics) , enhancer , function (biology) , computational biology , genetics , microbiology and biotechnology , transcription factor , gene , machine learning , computer science
New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex.
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