Deception through Mimicry: A Cellular Antiviral Strategy | Zendy

Nicholas C. Wu | Zendy; Andrew B. Ward | Zendy

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Deception through Mimicry: A Cellular Antiviral Strategy

Author(s) -

Nicholas C. Wu,

Andrew B. Ward

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.11.033

Subject(s) - biology , mimicry , nucleoprotein , ebola virus , interactome , virology , transcription factor , virus , molecular mimicry , deception , microbiology and biotechnology , genetics , antibody , gene , psychology , ecology , social psychology

Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.

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