Non-mendelian Inheritance in Mammals Is Highly Constrained | Zendy

Luke Isbel | Zendy; Dirk Schübeler | Zendy

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Non-mendelian Inheritance in Mammals Is Highly Constrained

Author(s) -

Luke Isbel,

Dirk Schübeler

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.10.046

Subject(s) - biology , epigenetics , genetics , inheritance (genetic algorithm) , mendelian inheritance , phenotype , allele , transgenerational epigenetics , dna methylation , evolutionary biology , heredity , non mendelian inheritance , gene , mitochondrial dna , gene expression

In this issue, Kazachenka, Bertozzi, and colleagues identify elements in the mouse genome with epigenetic variability between littermates, a phenomenon linked to transmission of phenotypes over generations. This addresses two questions that remained unanswered despite intense speculation: how prevalent are these alleles, and what is their effect, within and across generations?

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