Open AccessThe Helix Twist: Damage and Repair Follows the DNA Minor Groove
Author(s) -
Eran Kotler,
Eran Segal
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.10.034
Subject(s) - biology , minor groove , twist , helix (gastropod) , groove (engineering) , dna , dna damage , genetics , geometry , engineering , ecology , mathematics , snail , mechanical engineering
Mutation frequencies vary along the genome, but the factors determining this variability are only partially understood. Pich et al. unravel a ∼10 bp periodicity in mutation rates at nucleosome-proximal regions that follows minor groove orientation. Opposing differential DNA damage and repair processes could shape genetic divergence irrespective of selection.
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