Identification of the Human Skeletal Stem Cell | Zendy

Charles K. F. Chan | Zendy; Gunsagar S. Gulati | Zendy; Rahul Sinha | Zendy; Justin Vincent Tompkins | Zendy; Michael Lopez | Zendy; Ava C. Carter | Zendy; Ryan C. Ransom | Zendy; Andreas Reinisch | Zendy; Taylor Wearda | Zendy; Matthew P. Murphy | Zendy; Rachel Brewer | Zendy; Lauren S. Koepke | Zendy; Owen Marecic | Zendy; Anoop Manjunath | Zendy; Eun Young Seo | Zendy; Tripp Leavitt | Zendy; Wan-Jin Lu | Zendy; Allison Martin Nguyen | Zendy; Stephanie D. Conley | Zendy; Ankit Salhotra | Zendy; Thomas H. Ambrosi | Zendy; Mimi R. Borrelli | Zendy; Taylor Siebel | Zendy; Karen K. L. Chan | Zendy; Katharina Schallmoser | Zendy; Jun Seita | Zendy; Debashis Sahoo | Zendy; Henry Goodnough | Zendy; Julius A. Bishop | Zendy; Michael J. Gardner | Zendy; Ravindra Majeti | Zendy; Derrick C. Wan | Zendy; Stuart B. Goodman | Zendy; Irving L. Weissman | Zendy; Howard Y. Chang | Zendy; Michael T. Longaker | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Identification of the Human Skeletal Stem Cell

Author(s) -

Charles K. F. Chan,

Gunsagar S. Gulati,

Rahul Sinha,

Justin Vincent Tompkins,

Michael Lopez,

Ava C. Carter,

Ryan C. Ransom,

Andreas Reinisch,

Taylor Wearda,

Matthew P. Murphy,

Rachel Brewer,

Lauren S. Koepke,

Owen Marecic,

Anoop Manjunath,

Eun Young Seo,

Tripp Leavitt,

Wan-Jin Lu,

Allison Martin Nguyen,

Stephanie D. Conley,

Ankit Salhotra,

Thomas H. Ambrosi,

Mimi R. Borrelli,

Taylor Siebel,

Karen K. L. Chan,

Katharina Schallmoser,

Jun Seita,

Debashis Sahoo,

Henry Goodnough,

Julius A. Bishop,

Michael J. Gardner,

Ravindra Majeti,

Derrick C. Wan,

Stuart B. Goodman,

Irving L. Weissman,

Howard Y. Chang,

Michael T. Longaker

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.07.029

Subject(s) - biology , identification (biology) , stem cell , computational biology , microbiology and biotechnology , evolutionary biology , genetics , ecology

Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing and multipotent human skeletal stem cell (hSSC) that generates progenitors of bone, cartilage, and stroma, but not fat. Self-renewing and multipotent hSSCs are present in fetal and adult bones and can also be derived from BMP2-treated human adipose stroma (B-HAS) and induced pluripotent stem cells (iPSCs). Gene expression analysis of individual hSSCs reveals overall similarity between hSSCs obtained from different sources and partially explains skewed differentiation toward cartilage in fetal and iPSC-derived hSSCs. hSSCs undergo local expansion in response to acute skeletal injury. In addition, hSSC-derived stroma can maintain human hematopoietic stem cells (hHSCs) in serum-free culture conditions. Finally, we combine gene expression and epigenetic data of mouse skeletal stem cells (mSSCs) and hSSCs to identify evolutionarily conserved and divergent pathways driving SSC-mediated skeletogenesis. VIDEO ABSTRACT.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research