Open AccessWhirling Platelets Away for Transfusion
Author(s) -
Camelia IancuRubin,
Ronald Hoffman,
Anna Ritá Migliaccio
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.07.018
Subject(s) - platelet , platelet transfusion , ex vivo , sepsis , aplastic anemia , biology , immunology , medicine , in vivo , intensive care medicine , microbiology and biotechnology , bone marrow
With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs.
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