Open AccessDisease Heritability Studies Harness the Healthcare System to Achieve Massive Scale
Author(s) -
Joshua C. Denny,
Jonathan D. Mosley
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.05.053
Subject(s) - biology , scale (ratio) , heritability , disease , evolutionary biology , pathology , medicine , physics , quantum mechanics
Heritability studies are essential for defining genetic influences on disease risk and trait variability. Polubriaginof et al. show how massive amounts of data contained in electronic health records can be used for heritability studies on hundreds of phenotypes. Mining emergency contact information with comparison to existing gold standards showcases the broad utility of the approach.
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