Open AccessChemistry Takes Center Stage for Identifying Cancer Targetability
Author(s) -
Christopher G. Parker,
Benjamin F. Cravatt
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.04.020
Subject(s) - biology , center (category theory) , cancer , computational biology , stage (stratigraphy) , genetics , chemistry , paleontology , crystallography
Matching genetically defined cancer states to drugs that specifically target these states is a principal goal of personalized oncology medicine. In this issue, McMillan et al. show how large-scale chemical screening coupled to deep molecular profiling can identify mechanistically diverse druggable vulnerabilities for genetic subtypes of lung cancers.
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