Open AccessBeyond the Transport Function of Import Receptors: What’s All the FUS about?
Author(s) -
Sofya Mikhaleva,
Edward A. Lemke
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.04.002
Subject(s) - biology , function (biology) , receptor , microbiology and biotechnology , computational biology , genetics
Nuclear import receptors are central players in transporting protein cargoes into the nucleus. Moving beyond this role, four newly published articles describe a function in regulating supramolecular assemblies by fine-tuning the phase separating properties of RNA-binding proteins, which has implications for a variety of devastating neurodegenerative disorders.
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