Open AccessUsing Metagenomics to Characterize an Expanding Virosphere
Author(s) -
Yǒng-Zhèn Zhāng,
Mǎng Shī,
Edward C. Holmes
Publication year - 2018
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2018.02.043
Subject(s) - metagenomics , biology , genome , computational biology , evolutionary biology , genetics , gene
We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the "dark matter" of divergent viral genomes.
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