Antibiotic Resistance | Zendy

Idan Yelin | Zendy; Roy Kishony | Zendy

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Antibiotic Resistance

Author(s) -

Idan Yelin,

Roy Kishony

Publication year - 2018

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2018.02.018

Subject(s) - biology , point mutation , drug resistance , gene , genetics , mutation , antibiotic resistance , microbial genetics , computational biology , antibiotics , microbiology and biotechnology

Bacterial mechanisms of drug resistance operate at sequential lines of defense tackling drug at entry, accumulation, target binding, or downstream toxicity. These mechanisms are encoded by genomic changes ranging in scale from point mutations, through assembly of preexisting genetic elements, to horizontal import of genes from the environment. A many-to-many relationship prevails between resistance mechanisms and the spectrum of genetic changes encoding them.

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