Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis | Zendy

Irina Matei | Zendy; Han Sang Kim | Zendy; David Lyden | Zendy

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Unshielding Exosomal RNA Unleashes Tumor Growth And Metastasis

Author(s) -

Irina Matei,

Han Sang Kim,

David Lyden

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2017.06.047

Subject(s) - biology , microvesicles , metastasis , stroma , tumor microenvironment , cancer research , tumor progression , rna , receptor , microbiology and biotechnology , microrna , cancer , tumor cells , immunology , gene , genetics , immunohistochemistry

Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.

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