Emerging Biological Principles of Metastasis | Zendy

Arthur W. Lambert | Zendy; Diwakar R. Pattabiraman | Zendy; Robert A. Weinberg | Zendy

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Emerging Biological Principles of Metastasis

Author(s) -

Arthur W. Lambert,

Diwakar R. Pattabiraman,

Robert A. Weinberg

Publication year - 2017

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.11.037

Subject(s) - biology , metastasis , cancer metastasis , cancer , focus (optics) , genetics , physics , optics

Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.

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