CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes | Zendy

Alexis C. Komor | Zendy; Ahmed H. Badran | Zendy; David R. Liu | Zendy

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CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Author(s) -

Alexis C. Komor,

Ahmed H. Badran,

David R. Liu

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.10.044

Subject(s) - crispr , biology , genome editing , computational biology , cas9 , genome , endonuclease , dna , genetics , gene

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living cells. In this Review, we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications. We describe recent developments that extend the generality, DNA specificity, product selectivity, and fundamental capabilities of natural CRISPR systems, and we highlight some of the remarkable advancements in basic research, biotechnology, and therapeutics science that these developments have facilitated.

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