Open AccessLifting the Differentiation Embargo
Author(s) -
AnneLouise Latif,
Tessa L. Holyoake
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.08.051
Subject(s) - biology , psychological repression , myeloid leukemia , abnormality , mechanism (biology) , cellular differentiation , genetics , computational biology , cancer research , gene , gene expression , philosophy , epistemology , psychology , social psychology
Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.
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