Open AccessGetting IN on Viral RNA Condensation and Virion Maturation
Author(s) -
Eric O. Freed
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.08.013
Subject(s) - biology , integrase , viral replication , virology , reverse transcriptase , group specific antigen , rna , viral life cycle , dna , virus , microbiology and biotechnology , genetics , gene
The retroviral enzyme integrase plays an essential role in the virus replication cycle by catalyzing the covalent insertion of newly synthesized viral DNA into the host cell chromosome early after infection. Now, Kessl et al. report a second function of integrase: binding to the viral RNA genome in virion particles late in the virus replication cycle to promote particle maturation.
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