Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine | Zendy

Maximilian W. Popp | Zendy; Lynne E. Maquat | Zendy

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Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

Author(s) -

Maximilian W. Popp,

Lynne E. Maquat

Publication year - 2016

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2016.05.053

Subject(s) - nonsense mediated decay , biology , crispr , genome editing , nonsense , computational biology , cas9 , genome , messenger rna , gene , disease , personalized medicine , genetics , rna , medicine , pathology , rna splicing

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.

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