Open AccessThe Molecular Harbingers of Early Mammalian Embryo Patterning
Author(s) -
Jun Wu,
Juan Carlos Izpisúa Belmonte
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.03.005
Subject(s) - biology , embryo , evolutionary biology , cell fate determination , microbiology and biotechnology , lineage (genetic) , cell lineage , genetics , cellular differentiation , gene , transcription factor
Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.
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