Open AccessCASTORing New Light on Amino Acid Sensing
Author(s) -
James E Hughes Hallett,
Brendan D. Manning
Publication year - 2016
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2016.03.002
Subject(s) - biology , mtorc1 , arginine , regulator , intracellular , microbiology and biotechnology , amino acid , cell , biochemistry , signal transduction , gene , pi3k/akt/mtor pathway
The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. In this issue of Cell, Chantranupong et al. identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.
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