Evolutionary Reprograming of Protein-Protein Interaction Specificity | Zendy

Eyal Akiva | Zendy; Patricia C. Babbitt | Zendy

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Evolutionary Reprograming of Protein-Protein Interaction Specificity

Author(s) -

Eyal Akiva,

Patricia C. Babbitt

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.10.010

Subject(s) - biology , protein–protein interaction , protein evolution , mutation , computational biology , genetics , biological evolution , evolutionary biology , gene

Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via "intermediate" proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly general principles.

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