Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Zendy

Giovanni Ciriello | Zendy; Michael L. Gatza | Zendy; Andrew H. Beck | Zendy; Matthew D. Wilkerson | Zendy; Suhn K. Rhie | Zendy; Alessandro Pastore | Zendy; Hailei Zhang | Zendy; Michael D. McLellan | Zendy; Christina Yau | Zendy; Cyriac Kandoth | Zendy; Reanne Bowlby | Zendy; Hui Shen | Zendy; Sikander Hayat | Zendy; Robert J. Fieldhouse | Zendy; Susan C. Lester | Zendy; Gary M. Tse | Zendy; Rachel E. Factor | Zendy; Laura C. Collins | Zendy; Kimberly H. Allison | Zendy; Yunn-Yi Chen | Zendy; Kristin C. Jensen | Zendy; Nicole B. Johnson | Zendy; Steffi Oesterreich | Zendy; Gordon B. Mills | Zendy; Andrew D. Cherniack | Zendy; Gordon Robertson | Zendy; Christopher C. Benz | Zendy; Chris Sander | Zendy; Peter W. Laird | Zendy; Katherine A. Hoadley | Zendy; Tari A. King | Zendy; Charles M. Perou | Zendy; Rehan Akbani | Zendy; J. Todd Auman | Zendy; Miruna Balasundaram | Zendy; Saianand Balu | Zendy; Thomas Barr | Zendy; Stephen C. Benz | Zendy; Mario Berríos | Zendy; Rameen Beroukhim | Zendy; Tom Bodenheimer | Zendy; Lori Boice | Zendy; Arnoud Boot | Zendy; Jay Bowen | Zendy; Denise Brooks | Zendy; Lynda Chin | Zendy; Juok Cho | Zendy; Sudha Chudamani | Zendy; Tanja M. Davidsen | Zendy; John A. Demchok | Zendy; Jennifer B. Dennison | Zendy; Li Ding | Zendy; Ina Felau | Zendy; Martin L. Ferguson | Zendy; Scott Frazer | Zendy; Stacey Gabriel | Zendy; Jianjiong Gao | Zendy; Julie M. Gastier-Foster | Zendy; Nils Gehlenborg | Zendy; Mark Gerken | Zendy; Gad Getz | Zendy; William J. Gibson | Zendy; D. Neil Hayes | Zendy; David I. Heiman | Zendy; Andrea Holbrook | Zendy; Robert A. Holt | Zendy; Alan P. Hoyle | Zendy; Hai Hu | Zendy; Mei Huang | Zendy; Carolyn M. Hutter | Zendy; E. Shelley Hwang | Zendy; Joshua M. Stuart | Zendy; Steven J.M. Jones | Zendy; Zhenlin Ju | Zendy; Jaegil Kim | Zendy; Phillip H. Lai | Zendy; Michael S. Lawrence | Zendy; Kristen M. Leraas | Zendy; Tara M. Lichtenberg | Zendy; Pei Lin | Zendy; Shiyun Ling | Zendy; Jia Liu | Zendy; Wenbin Liu | Zendy; Laxmi Lolla | Zendy; Yiling Lu | Zendy; Yussanne Ma | Zendy; Dennis T. Maglinte | Zendy; Elaine R. Mardis | Zendy; Jeffrey R. Marks | Zendy; Marco A. Marra | Zendy; Cynthia McAllister | Zendy; Shaowu Meng | Zendy; Matthew Meyerson | Zendy; Richard A. Moore | Zendy; Lisle E. Mose | Zendy; Andrew J. Mungall | Zendy; Bradley A. Murray | Zendy; Rashi Naresh | Zendy; Michael S. Noble | Zendy; Olufunmilayo Olopade | Zendy; Peter J. Park | Zendy; Todd Pihl | Zendy; Gordon Saksena | Zendy; Steven E. Schumacher | Zendy; Kenna Shaw | Zendy; Nilsa C. Ramirez | Zendy; W. Kimryn Rathmell | Zendy; Jeffrey Roach | Zendy; A. Gordon Robertson | Zendy; Jacqueline E. Schein | Zendy; Nikolaus Schultz | Zendy; Margi Sheth | Zendy; Yan Shi | Zendy; Juliann Shih | Zendy; Carl Simon Shelley | Zendy; Craig D. Shriver | Zendy; Janae V. Simons | Zendy; Heidi J. Sofia | Zendy; Matthew G. Soloway | Zendy; Carrie Sougnez | Zendy; Charlie Sun | Zendy; Roy Tarnuzzer | Zendy; Daniel Guimarães Tiezzi | Zendy; David Van Den Berg | Zendy; Doug Voet | Zendy; Yunhu Wan | Zendy; Linghua Wang | Zendy; John N. Weinstein | Zendy; Daniel J. Weisenberger | Zendy; Richard K. Wilson | Zendy; Lisa Wise | Zendy; Maciej Wiznerowicz | Zendy; Junyuan Wu | Zendy; Ye Wu | Zendy; Liming Yang | Zendy; Travis Zack | Zendy; Jean C. Zenklusen | Zendy; Jiashan Zhang | Zendy; Erik Zmuda | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

Author(s) -

Giovanni Ciriello,

Michael L. Gatza,

Andrew H. Beck,

Matthew D. Wilkerson,

Suhn K. Rhie,

Alessandro Pastore,

Hailei Zhang,

Michael D. McLellan,

Christina Yau,

Cyriac Kandoth,

Reanne Bowlby,

Hui Shen,

Sikander Hayat,

Robert J. Fieldhouse,

Susan C. Lester,

Gary M. Tse,

Rachel E. Factor,

Laura C. Collins,

Kimberly H. Allison,

Yunn-Yi Chen,

Kristin C. Jensen,

Nicole B. Johnson,

Steffi Oesterreich,

Gordon B. Mills,

Andrew D. Cherniack,

Gordon Robertson,

Christopher C. Benz,

Chris Sander,

Peter W. Laird,

Katherine A. Hoadley,

Tari A. King,

Charles M. Perou,

Rehan Akbani,

J. Todd Auman,

Miruna Balasundaram,

Saianand Balu,

Thomas Barr,

Stephen C. Benz,

Mario Berríos,

Rameen Beroukhim,

Tom Bodenheimer,

Lori Boice,

Arnoud Boot,

Jay Bowen,

Denise Brooks,

Lynda Chin,

Juok Cho,

Sudha Chudamani,

Tanja M. Davidsen,

John A. Demchok,

Jennifer B. Dennison,

Li Ding,

Ina Felau,

Martin L. Ferguson,

Scott Frazer,

Stacey Gabriel,

Jianjiong Gao,

Julie M. Gastier-Foster,

Nils Gehlenborg,

Mark Gerken,

Gad Getz,

William J. Gibson,

D. Neil Hayes,

David I. Heiman,

Andrea Holbrook,

Robert A. Holt,

Alan P. Hoyle,

Hai Hu,

Mei Huang,

Carolyn M. Hutter,

E. Shelley Hwang,

Joshua M. Stuart,

Steven J.M. Jones,

Zhenlin Ju,

Jaegil Kim,

Phillip H. Lai,

Michael S. Lawrence,

Kristen M. Leraas,

Tara M. Lichtenberg,

Pei Lin,

Shiyun Ling,

Jia Liu,

Wenbin Liu,

Laxmi Lolla,

Yiling Lu,

Yussanne Ma,

Dennis T. Maglinte,

Elaine R. Mardis,

Jeffrey R. Marks,

Marco A. Marra,

Cynthia McAllister,

Shaowu Meng,

Matthew Meyerson,

Richard A. Moore,

Lisle E. Mose,

Andrew J. Mungall,

Bradley A. Murray,

Rashi Naresh,

Michael S. Noble,

Olufunmilayo Olopade,

Peter J. Park,

Todd Pihl,

Gordon Saksena,

Steven E. Schumacher,

Kenna Shaw,

Nilsa C. Ramirez,

W. Kimryn Rathmell,

Jeffrey Roach,

A. Gordon Robertson,

Jacqueline E. Schein,

Nikolaus Schultz,

Margi Sheth,

Yan Shi,

Juliann Shih,

Carl Simon Shelley,

Craig D. Shriver,

Janae V. Simons,

Heidi J. Sofia,

Matthew G. Soloway,

Carrie Sougnez,

Charlie Sun,

Roy Tarnuzzer,

Daniel Guimarães Tiezzi,

David Van Den Berg,

Doug Voet,

Yunhu Wan,

Linghua Wang,

John N. Weinstein,

Daniel J. Weisenberger,

Richard K. Wilson,

Lisa Wise,

Maciej Wiznerowicz,

Junyuan Wu,

Ye Wu,

Liming Yang,

Travis Zack,

Jean C. Zenklusen,

Jiashan Zhang,

Erik Zmuda

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.09.033

Subject(s) - biology , invasive lobular carcinoma , foxa1 , pten , cancer research , breast cancer , gata3 , pi3k/akt/mtor pathway , cancer , invasive ductal carcinoma , genetics , gene , transcription factor , signal transduction

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research