Open AccessAn AAA+ ATPase Clamshell Targets Transposition
Author(s) -
Chi-Lin Tsai,
Gareth J. Williams,
J. Jefferson P. Perry,
John A. Tainer
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.07.050
Subject(s) - biology , transposition (logic) , atpase , genetics , computational biology , microbiology and biotechnology , biochemistry , philosophy , linguistics , enzyme
DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.
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