Open AccessSomatic Rearrangement in B Cells: It’s (Mostly) Nuclear Physics
Author(s) -
E Aiden,
Rafael Casellas
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.07.034
Subject(s) - biology , somatic cell , selection (genetic algorithm) , gene , chromosomal translocation , genetics , dna , gene rearrangement , microbiology and biotechnology , artificial intelligence , computer science
We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection.
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