Genetic Variation Meets Replication Origins | Zendy

Ronald J. Hause | Zendy; Jay Shendure | Zendy

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Genetic Variation Meets Replication Origins

Author(s) -

Ronald J. Hause,

Jay Shendure

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.11.009

Subject(s) - biology , replication (statistics) , variation (astronomy) , evolutionary biology , genetics , genetic variation , computational biology , gene , virology , physics , astrophysics

Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.

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