Open AccessDistinctive tRNA Repertoires in Proliferating versus Differentiating Cells
Author(s) -
Ivan Topisirović,
Nahum Sonenberg
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.08.031
Subject(s) - biology , transfer rna , genetics , microbiology and biotechnology , evolutionary biology , computational biology , rna , gene
Transfer RNAs (tRNAs) deliver amino acids to the ribosome during mRNA translation. Gingold et al. now provide evidence that alterations in the cellular tRNA repertoire are tightly coordinated with changes in mRNA expression. These changes in the tRNA repertoire dictate translational programs that distinguish differentiating from proliferating cells.
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