A Timeless but Timely Connection between Replication and Recombination | Zendy

Valérie Borde | Zendy; Michael Lichten | Zendy

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A Timeless but Timely Connection between Replication and Recombination

Author(s) -

Valérie Borde,

Michael Lichten

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.07.029

Subject(s) - biology , origin recognition complex , dna replication , replication (statistics) , control of chromosome duplication , genetics , timeless , pre replication complex , homologous recombination , replication factor c , minichromosome maintenance , mechanism (biology) , microbiology and biotechnology , recombination , licensing factor , semiconservative replication , eukaryotic dna replication , dna , gene , virology , neuroscience , circadian rhythm , philosophy , epistemology

Initiation of meiotic recombination by DNA double-strand break formation is temporally coordinated with replication. Murakami and Keeney show that this coordination requires recruitment of the Dbf4-dependent kinase to the replication fork by the conserved TIM-TIPIN complex. The same mechanism may regulate other important replication-associated processes.

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