Open AccessYAP1 Takes Over when Oncogenic K-Ras Slumbers
Author(s) -
Florian R. Greten
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.06.021
Subject(s) - biology , yap1 , genetics , microbiology and biotechnology , cancer research , gene , transcription factor
It is of great therapeutic importance to understand why tumors relapse after the failure of therapies targeting oncogenes to which cancer cells are addicted. In this issue, Kapoor et al. and Shao et al. identify the transcriptional coactivator YAP1 as a central driver of compensation for the loss of K-Ras signaling in K-Ras-dependent cancers.
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