The Search for Antiaging Interventions: From Elixirs to Fasting Regimens | Zendy

Rafael de Cabo | Zendy; Didac CarmonaGutiérrez | Zendy; Michel Bernier | Zendy; Michael N. Hall | Zendy; Frank Madeo | Zendy

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

Author(s) -

Rafael de Cabo,

Didac CarmonaGutiérrez,

Michel Bernier,

Michael N. Hall,

Frank Madeo

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.05.031

Subject(s) - proteostasis , biology , autophagy , psychological intervention , senescence , caloric theory , neuroscience , longevity , nutrient sensing , bioinformatics , microbiology and biotechnology , psychology , signal transduction , genetics , endocrinology , apoptosis , psychiatry

The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to manipulate it has fascinated humans likely since time immemorial. Recent evidence is shaping a picture where low caloric regimes and exercise may improve healthy senescence, and several pharmacological strategies have been suggested to counteract aging. Surprisingly, the most effective interventions proposed to date converge on only a few cellular processes, in particular nutrient signaling, mitochondrial efficiency, proteostasis, and autophagy. Here, we critically examine drugs and behaviors to which life- or healthspan-extending properties have been ascribed and discuss the underlying molecular mechanisms.

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