Open AccessMutant PTEN in Cancer: Worse Than Nothing
Author(s) -
Nicholas R. Leslie,
Jeroen den Hertog
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.04.008
Subject(s) - pten , biology , suppressor , cancer , mutant , tumor suppressor gene , cancer research , cancer cell , phenotype , gene , genetics , carcinogenesis , pi3k/akt/mtor pathway , signal transduction
Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.
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