Neurogenesis in the Striatum of the Adult Human Brain | Zendy

Aurélie Ernst | Zendy; Kanar Alkass | Zendy; Samuel Bernard | Zendy; Mehran Salehpour | Zendy; Shira Perl | Zendy; John F. Tisdale | Zendy; Göran Possnert | Zendy; Henrik Druid | Zendy; Jonas Frisén | Zendy

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Neurogenesis in the Striatum of the Adult Human Brain

Author(s) -

Aurélie Ernst,

Kanar Alkass,

Samuel Bernard,

Mehran Salehpour,

Shira Perl,

John F. Tisdale,

Göran Possnert,

Henrik Druid,

Jonas Frisén

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.01.044

Subject(s) - biology , neurogenesis , striatum , neuroscience , human brain , dopamine

In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.

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