Open AccessDivergent Transcription: A Driving Force for New Gene Origination?
Author(s) -
Xuebing Wu,
Phillip A. Sharp
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.10.048
Subject(s) - biology , origination , transcription (linguistics) , gene , genetics , transcription factor , evolutionary biology , computational biology , philosophy , linguistics , computer network , computer science
The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
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