First Steps toward a Globally Effective HIV/AIDS Vaccine | Zendy

David Palesch | Zendy; Frank Kirchhoff | Zendy

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First Steps toward a Globally Effective HIV/AIDS Vaccine

Author(s) -

David Palesch,

Frank Kirchhoff

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.10.012

Subject(s) - biology , simian immunodeficiency virus , virology , epitope , human immunodeficiency virus (hiv) , aids vaccines , hiv vaccine , immunology , immune system , antigen , virus , vaccine trial

The enormous diversity of HIV-1 presents a formidable challenge for developing an effective AIDS vaccine. In this issue of Cell, Barouch et al. show that bioinformatically designed antigens, pieced together from multiple HIV immune epitopes, partially protect rhesus macaques from simian-human immunodeficiency virus infection. This "mosaic" approach holds promise for the development of broadly protective vaccines.

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