Mechanistic Interpretation of Promoter-Proximal Peaks and RNAPII Density Maps | Zendy

Andreas H. Ehrensberger | Zendy; Gavin Kelly | Zendy; Jesper Q. Svejstrup | Zendy

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Mechanistic Interpretation of Promoter-Proximal Peaks and RNAPII Density Maps

Author(s) -

Andreas H. Ehrensberger,

Gavin Kelly,

Jesper Q. Svejstrup

Publication year - 2013

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2013.07.032

Subject(s) - rna polymerase ii , transcription (linguistics) , processivity , biology , elongation , elongation factor , gene , gene expression , physics , polymerase , genetics , promoter , rna , materials science , linguistics , philosophy , ribosome , ultimate tensile strength , metallurgy

Genome-wide RNA polymerase II (RNAPII) density profiles provide averaged snapshots of transcription but are difficult to interpret in the context of dynamic gene expression. We performed computational modeling to simulate RNAPII density profiles from individual transcription parameters and constructed simple mathematical models to explore general relationships between transcription parameters and density profiles.

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