Open AccessPyruvate as a Pivot Point for Oncogene-Induced Senescence
Author(s) -
Benjamin A. Olenchock,
Matthew G. Vander Heiden
Publication year - 2013
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2013.06.001
Subject(s) - anabolism , biology , catabolism , warburg effect , pyruvate decarboxylation , metabolism , cellular respiration , glycolysis , microbiology and biotechnology , biochemistry , mitochondrion , citric acid cycle
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom